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cba caj mice  (Jackson Laboratory)

 
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    Jackson Laboratory cba caj mice
    Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cba caj mice/product/Jackson Laboratory
    Average 86 stars, based on 1 article reviews
    cba caj mice - by Bioz Stars, 2026-06
    86/100 stars

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    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) <t>(D-F)</t> <t>CBA/CaJ</t> mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.
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    cba caj mice  (Jackson Laboratory)
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    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) <t>(D-F)</t> <t>CBA/CaJ</t> mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.
    Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cba caj mice/product/Jackson Laboratory
    Average 86 stars, based on 1 article reviews
    cba caj mice - by Bioz Stars, 2026-06
    86/100 stars
    		  Buy from Supplier
    male cba caj mice  (Jackson Laboratory)
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    Jackson Laboratory male cba caj mice
    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) <t>(D-F)</t> <t>CBA/CaJ</t> mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.
    Male Cba Caj Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/male cba caj mice/product/Jackson Laboratory
    Average 86 stars, based on 1 article reviews
    male cba caj mice - by Bioz Stars, 2026-06
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) (D-F) CBA/CaJ mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A-F) Thirty µm mid-modiolar sections of the auditory nerve (AN) glial transition zone (GTZ) in a young (3 months) (A-C) and an aged (2.5 years) (D-F) CBA/CaJ mouse. Sections are stained with FluoroMyelin TM (green), macrophage/microglia cell marker Iba1 (red), and Hoechst nuclear stain (blue). The dashed white line indicates where the AN GTZ is located in a mid-modiolar section. Scale bar = 100 µm. (G) Representative image from Epon LX 112 resin-embedded sections (stained with Toluidine blue) of the AN GTZ in a 1 year-old mouse. (G’) Enlarged images of the white outlined region of the AN GTZ are shown to illustrate the visible gap between central and peripheral myelination in the AN.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining, Marker

    (A –X) Serial sections taken 25 μm apart from tissue cleared mouse temporal bones showing the entire AN within the cochlea and the AN GTZ in a young (3 months) (A-L) and an aged (2.5 years) (M-X) CBA/CaJ mouse. (D’, E’, I’) Enlarged images of the white outlined regions of the AN GTZ in a young mouse are shown. (P’, T’, V’) Enlarged images of the white outlined regions of the AN GTZ in an aged mouse are shown with a white arrow indicating CD68 + cells within the AN, while no CD68 + cells were seen in the AN of the young mouse (D’, E’, I’). Dashed white lines in D’, E’, I’, and P’ show the cone-shaped morphology of the AN GTZ. Dashed white lines in T’ and V’ show the GTZ in the basal turn/hook of the cochlea. Each mouse temporal bone was stained with Myelin Basic Protein (green) and CD68 (red). Scale bars = 200 µm for all images.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A –X) Serial sections taken 25 μm apart from tissue cleared mouse temporal bones showing the entire AN within the cochlea and the AN GTZ in a young (3 months) (A-L) and an aged (2.5 years) (M-X) CBA/CaJ mouse. (D’, E’, I’) Enlarged images of the white outlined regions of the AN GTZ in a young mouse are shown. (P’, T’, V’) Enlarged images of the white outlined regions of the AN GTZ in an aged mouse are shown with a white arrow indicating CD68 + cells within the AN, while no CD68 + cells were seen in the AN of the young mouse (D’, E’, I’). Dashed white lines in D’, E’, I’, and P’ show the cone-shaped morphology of the AN GTZ. Dashed white lines in T’ and V’ show the GTZ in the basal turn/hook of the cochlea. Each mouse temporal bone was stained with Myelin Basic Protein (green) and CD68 (red). Scale bars = 200 µm for all images.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining

    (A-B) FluoroMyelin TM -stained sections in the peripheral AN (A) and central AN (B) in a young (3 months) and aged (2.5 years) CBA/CaJ mouse. Boxes on the top-right are enlarged images from the dashed boxes in A and B. (C) Quantification of myelinated AN fiber surface area in young (filled green circles) and aged (open green circles). N= 4 mice per age group. 4 ROIs per mouse (2 ROIs for peripheral AN, 2 ROIs for central AN). The difference between the young and the aged was not significant. (D-E) FluoroMyelin TM -stained sections in the peripheral AN (D) and central AN (E) in an aged CBA/CaJ mice. Magenta dashed boxes indicate the region of the pop-out image in the magenta outlined box. Boxes on the top-right are enlarged images from the dashed boxes in D and E. White arrows indicate the disrupted myelin sheaths in the peripheral AN (D) and central AN (E). (F) Quantification of myelinated AN fiber volume by age group. N = 4 mice per age group. 4 ROIs per animal. The difference between the young and the aged was not significant. Diamonds represent the mean and error bars represent the standard deviation for each group. All distributions were tested for normality using a Kolmogorov-Smirnoff test. Significance was determined using a Mann-Whitney U-test, α = 0.05. Scale bar = 10 µm for all images.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A-B) FluoroMyelin TM -stained sections in the peripheral AN (A) and central AN (B) in a young (3 months) and aged (2.5 years) CBA/CaJ mouse. Boxes on the top-right are enlarged images from the dashed boxes in A and B. (C) Quantification of myelinated AN fiber surface area in young (filled green circles) and aged (open green circles). N= 4 mice per age group. 4 ROIs per mouse (2 ROIs for peripheral AN, 2 ROIs for central AN). The difference between the young and the aged was not significant. (D-E) FluoroMyelin TM -stained sections in the peripheral AN (D) and central AN (E) in an aged CBA/CaJ mice. Magenta dashed boxes indicate the region of the pop-out image in the magenta outlined box. Boxes on the top-right are enlarged images from the dashed boxes in D and E. White arrows indicate the disrupted myelin sheaths in the peripheral AN (D) and central AN (E). (F) Quantification of myelinated AN fiber volume by age group. N = 4 mice per age group. 4 ROIs per animal. The difference between the young and the aged was not significant. Diamonds represent the mean and error bars represent the standard deviation for each group. All distributions were tested for normality using a Kolmogorov-Smirnoff test. Significance was determined using a Mann-Whitney U-test, α = 0.05. Scale bar = 10 µm for all images.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: Staining, Standard Deviation, MANN-WHITNEY

    (A) Analysis of AN RNA-sequencing data from young (3 months) and aged (2.5 years) CBA/CaJ mice detects 1240 differentially expressed genes (Supplementary Table 1). (B) Enrichment analysis of differentially expressed genes detects significant effects on abnormal myelination and abnormal inflammatory response. (C) Expression patterns of differentially expressed genes linked to abnormal myelination, abnormal inflammatory response or both categories. For abnormal inflammatory response, the 15 genes showing highest upregulation are listed on the right.

    Journal: bioRxiv

    Article Title: A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

    doi: 10.64898/2026.03.27.714751

    Figure Lengend Snippet: (A) Analysis of AN RNA-sequencing data from young (3 months) and aged (2.5 years) CBA/CaJ mice detects 1240 differentially expressed genes (Supplementary Table 1). (B) Enrichment analysis of differentially expressed genes detects significant effects on abnormal myelination and abnormal inflammatory response. (C) Expression patterns of differentially expressed genes linked to abnormal myelination, abnormal inflammatory response or both categories. For abnormal inflammatory response, the 15 genes showing highest upregulation are listed on the right.

    Article Snippet: To quantify age-related changes in myelination in the AN, we measured the volume and surface area of myelinated fibers in young (3 - 4 months) and aged (≥ 2.5 years) CBA/CaJ mice using Imaris.

    Techniques: RNA Sequencing, Expressing